Vascular Actions of Calcitonin Gene-Related Peptide and Adrenomedullin
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چکیده
I. History and Discovery 904 A. Calcitonin gene-related peptide: a novel neuropeptide 904 B. Adrenomedullin: a tissue-derived peptide 905 C. Amylin: a pancreatic peptide 905 II. Structure 905 III. Distribution and Regulation of Genes and Peptides 906 A. CGRP: a wide distribution 906 B. AM: upregulation in disease 907 C. Amylin: relevance to diabetes 908 IV. Receptors 908 A. Cloning of CGRP receptors 908 B. CL and RAMPs 909 C. CGRP receptor antagonists 910 V. Vasodilator Mechanisms 911 A. CGRP: multiple mechanisms 911 B. AM: active on CGRP and AM receptors 912 C. Amylin: active via the CGRP1 receptor 913 VI. Cardiovascular Regulation 913 A. CGRP: potent vasodilator in vivo 913 B. AM: role in regulating blood pressure 914 VII. Microvascular Mechanisms 915 A. CGRP: a protective factor? 915 B. AM: heterogeneity in response 916 VIII. Inflammation and Vascular Biology 916 A. CGRP: cellular effects 916 B. AM: cellular effects 918 IX. Involvement in Cardiovascular Disease 919 A. CGRP and cerebral conditions 919 B. CGRP and AM: heart conditions 919 C. AM and hypertension 920 D. CGRP and AM: pulmonary hypertension 920 E. CGRP and AM: sepsis 921 F. CGRP and Raynaud’s disease 921 G. CGRP and blushing syndromes 922 X. Conclusion and Future Perspectives 922
منابع مشابه
Vascular actions of calcitonin gene-related peptide and adrenomedullin.
This review summarizes the receptor-mediated vascular activities of calcitonin gene-related peptide (CGRP) and the structurally related peptide adrenomedullin (AM). CGRP is a 37-amino acid neuropeptide, primarily released from sensory nerves, whilst AM is produced by stimulated vascular cells, and amylin is secreted from the pancreas. They share vasodilator activity, albeit to varying extents d...
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I. History and Discovery 904 A. Calcitonin gene-related peptide: a novel neuropeptide 904 B. Adrenomedullin: a tissue-derived peptide 905 C. Amylin: a pancreatic peptide 905 II. Structure 905 III. Distribution and Regulation of Genes and Peptides 906 A. CGRP: a wide distribution 906 B. AM: upregulation in disease 907 C. Amylin: relevance to diabetes 908 IV. Receptors 908 A. Cloning of CGRP rece...
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